abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：:Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence of ozone (O(3)) exposure prior to infection, is sex dependent. The objective of this work was to study the role of gonadal hormones, 5α-dihydrotestosterone (DHT) and 17β-estradiol (E(2)), o...

journal_title：Experimental lung research

authors： Durrani F,Phelps DS,Weisz J,Silveyra P,Hu S,Mikerov AN,Floros J

更新日期：2012-05-01 00:00:00

abstract：:Nicotine appears to be the primary pharmacologic agent that causes smoking-related pulmonary diseases. An understanding of the effect of nicotine on lungs is essential to develop interventions that can be used to counter smoking-related diseases. Further, it is shown that physical exercise may partially reverse smokin...

journal_title：Experimental lung research

authors： Al-Obaidi S,Mathew TC,Dean E

更新日期：2012-05-01 00:00:00

abstract：:Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...

journal_title：Experimental lung research

authors： Fei D,Meng X,Kang K,Nan C,Zhao M,Pan S,Gao M,Yang S,Zhao M

更新日期：2012-05-01 00:00:00

abstract：:Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this study was to evaluate the effect of neutrop...

journal_title：Experimental lung research

authors： Fujino N,Kubo H,Suzuki T,He M,Suzuki T,Yamada M,Takahashi T,Ota C,Yamaya M

更新日期：2012-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by systemic and local chronic inflammation and oxidative stress. The sources of the increased oxidative stress in COPD patients derive from the increased burden of inhaled oxidants such as cigarette smoke and other forms of particulate or gaseous air pollut...

journal_title：Experimental lung research

authors： Lakhdar R,Denden S,Kassab A,Leban N,Knani J,Lefranc G,Miled A,Chibani JB,Khelil AH

更新日期：2011-08-01 00:00:00

abstract：:Retention in the extrathoracic airways, and clearance by nose blowing, of monodisperse indium-111-labeled polystyrene particles were followed for at least 2 days after inhalation by healthy volunteers. Nine volunteers inhaled 3-μm aerodynamic diameter particles while sitting at rest, whereas subgroups of 3 or 4 inhale...

journal_title：Experimental lung research

authors： Smith JR,Bailey MR,Etherington G,Shutt AL,Youngman MJ

更新日期：2011-03-01 00:00:00

abstract：:Chymase is a chymotrypsin-like serine protease that is present in mast cells. Its activities include various effects associated with inflammatory responses. But little is known about the effects of chymase in pulmonary fibrosis. The mouse silicosis model was induced by intratracheal injection of 10 mg silica. The Ashc...

journal_title：Experimental lung research

authors： Takato H,Yasui M,Ichikawa Y,Waseda Y,Inuzuka K,Nishizawa Y,Tagami A,Fujimura M,Nakao S

更新日期：2011-03-01 00:00:00

abstract：:The separate effects of positive end-expiratory pressure (PEEP) and intravascular volume administration on the histopathologic lung injury were not investigated in experimental lung injury previously. The authors hypothesized that high PEEP and a restrictive volume therapy would yield the best oxygenation and the leas...

journal_title：Experimental lung research

authors： Kredel M,Muellenbach RM,Schlegel N,Wunder C,Klingelhöfer M,Lange M,Roewer N,Waschke J,Brederlau J

更新日期：2011-02-01 00:00:00

abstract：:Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hyp...

journal_title：Experimental lung research

authors： Duan S,Zhang Y,Wu SJ,Jiang LZ,Zhang J,Gan Y,Chen P,Zhao SP,Li GY

更新日期：2010-12-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:Inflammation plays a key role in lung injury and in the pathogenesis of asthma. Two murine models of allergic airway inflammation-sensitization and challenge to ovalbumin (OVA) and intratracheal exposure to interleukin-13 (IL13)-were used to evaluate the expression of poly(ADP-ribose) polymerase-1 (PARP-1) in allergic...

journal_title：Experimental lung research

authors： Havranek T,Aujla PK,Nickola TJ,Rose MC,Scavo LM

更新日期：2010-09-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) during hyperoxia contribute to alveolar epithelial apoptosis. In the present study, the molecular mechanisms of oxidative stress-induced alveolar epithelial cell apoptosis were investigated. The cytoprotective effects of N-acetylcysteine (NAC) were evaluated. Treatments ...

journal_title：Experimental lung research

authors： Fu YQ,Fang F,Lu ZY,Kuang FW,Xu F

更新日期：2010-08-01 00:00:00

abstract：:Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signal...

journal_title：Experimental lung research

authors： Woo HJ,Yoo WJ,Bae CH,Song SY,Kim YW,Park SY,Kim YD

更新日期：2010-06-01 00:00:00

abstract：:Studies demonstrated that pathophysiological abnormalities of airway smooth muscle (ASM) contribute significantly to chronic obstructive pulmonary disease (COPD) pathogenesis, the aim of this study is to investigate heat shock protein 70 (Hsp70) in ASM in COPD. ASM from 8 COPD patients and 6 controls were isolated for...

journal_title：Experimental lung research

authors： Xie J,Zhao J,Xiao C,Xu Y,Yang S,Ni W

更新日期：2010-05-01 00:00:00

abstract：:Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1...

journal_title：Experimental lung research

authors： Biaggio VS,Pérez Chaca MV,Valdéz SR,Gómez NN,Gimenez MS

更新日期：2010-02-01 00:00:00

abstract：:Nuclear factor kappa B (NF-kappa B) is a critical transcription factor for the production of many inflammatory cytokines. It is activated in the airway epithelium of human asthmatics and in mice after allergic stimulation. To examine the role of NF-kappa B activation in allergic inflammation, the authors generated tra...

journal_title：Experimental lung research

authors： Sheller JR,Polosukhin VV,Mitchell D,Cheng DS,Peebles RS,Blackwell TS

更新日期：2009-12-01 00:00:00

abstract：:Both hyperoxia-induced proapoptotic sensitization of alveolar type II cells (TII cells) and high-stretch mechanical ventilation induced pulmonary inflammation are tumor necrosis factor alpha (TNFalpha) mediated. Therefore, binding of free TNFalpha should protect from TNFalpha-mediated acute lung injury and ameliorate ...

journal_title：Experimental lung research

authors： Guthmann F,Wissel H,Rüstow B

更新日期：2009-11-01 00:00:00

abstract：:Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...

journal_title：Experimental lung research

authors： Miko E,Czimmerer Z,Csánky E,Boros G,Buslig J,Dezso B,Scholtz B

更新日期：2009-10-01 00:00:00

abstract：:The objective of this study was to determine if prolonged hyperoxia exposure would deplete antioxidants, resulting in excessive oxidative stress that would lead to oxidation of pulmonary surfactant and contribute to lung dysfunction. Rats were exposed to either hyperoxic (> 95% O(2)) or normoxic (21% O(2)) oxygen conc...

journal_title：Experimental lung research

authors： Pace PW,Yao LJ,Wilson JX,Possmayer F,Veldhuizen RA,Lewis JF

更新日期：2009-06-01 00:00:00

abstract：:The objective of this study was to evaluate the protective effects of resveratrol on lung injury in rats with severe acute pancreatitis. Ninety-six male Sprague-Dawley rats were randomly classified into 4 equal groups (n = 24): control, model, resveratrol-treated, and dexamethasone-treated. The rats were evaluated at ...

journal_title：Experimental lung research

authors： Sha H,Ma Q,Jha RK,Wang Z

更新日期：2009-05-01 00:00:00

abstract：:Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung. This study further examines the pulmonary expression of nitric oxide synthase (NOS) isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury (S+B injury). Female range bred sheep (4 pe...

journal_title：Experimental lung research

authors： Cox RA,Jacob S,Oliveras G,Murakami K,Enkhbaatar P,Traber L,Schmalstieg FC,Herndon DN,Traber DL,Hawkins HK

更新日期：2009-03-01 00:00:00

abstract：:The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 micro g/kg) on da...

journal_title：Experimental lung research

authors： Yuksel H,Yilmaz O,Baytur YB,Ozbilgin K

更新日期：2008-11-01 00:00:00

abstract：:Long-term, low-dose macrolide therapy has been proven to improve survival in patients with diffuse panbronchiolitis and cystic fibrosis, although the mechanisms by which it does so remain unknown. To elucidate the molecular mechanisms of the anti-inflammatory effects of macrolides, the authors examined the effects of ...

journal_title：Experimental lung research

authors： Yu C,Azuma A,Li Y,Wang C,Abe S,Usuki J,Matsuda K,Kudoh S,Sunazuka T,Omura S

更新日期：2008-08-01 00:00:00

abstract：:Tracheal occlusion (TO) performed surgically in utero near the end of gestation causes a rapid increase in the distension of future airspaces, resulting in accelerated lung development. The authors hypothesize that TO stimulates microvascular growth concomitant with a rapid increase in the expression of genes implicat...

journal_title：Experimental lung research

authors： Cloutier M,Maltais F,Piedboeuf B

更新日期：2008-03-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：:Neutrophilic inflammation is responsible for much of the tissue damage seen in many lung diseases. For resolution of inflammation to occur, neutrophils must die by apoptosis, allowing their recognition and removal by macrophages. The molecular events controlling this important regulatory step are poorly understood, in...

journal_title：Experimental lung research

authors： Renshaw SA,Loynes CA,Elworthy S,Ingham PW,Whyte MK

更新日期：2007-12-01 00:00:00

abstract：:The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA a...

journal_title：Experimental lung research

authors： Idell S,Azghani A,Chen S,Koenig K,Mazar A,Kodandapani L,Bdeir K,Cines D,Kulikovskaya I,Allen T

更新日期：2007-10-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：:In vitro responses of potential target cell types to air pollutants under physiological conditions may be useful in understanding the health effects of air pollution exposure. The study evaluated responses of human primary airway epithelial cells to diesel exhaust (DE). Cultures of cells from 3 donors, differentiated ...

journal_title：Experimental lung research

authors： Seagrave J,Dunaway S,McDonald JD,Mauderly JL,Hayden P,Stidley C

更新日期：2007-01-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The...

journal_title：Experimental lung research

authors： Matsuzaki T,Amakawa K,Yamaguchi K,Ishizaka A,Terashima T,Matsumaru A,Morishita T

更新日期：2006-10-01 00:00:00

abstract：:Toluene diisocyanate (TDI) is known as one of causes of occupational asthma and hypersensitivity pneumonitis. To investigate the stimulatory effect on bronchial epithelial cells in response to TDI, the authors examined production of cytokines by the bronchial epithelial cell line BEAS-2B and intercellular signal trans...

journal_title：Experimental lung research

authors： Ogawa H,Inoue S,Ogushi F,Ogura H,Nakamura Y

更新日期：2006-06-01 00:00:00

abstract：:Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine m...

journal_title：Experimental lung research

authors： Suh GY,Ham HS,Lee SH,Choi JC,Koh WJ,Kim SY,Lee J,Han J,Kim HP,Choi AM,Kwon OJ

更新日期：2006-01-01 00:00:00

abstract：:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor...

journal_title：Experimental lung research

authors： da Hora K,Valença SS,Porto LC

更新日期：2005-10-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：:The lung is affected by a variety of disease processes that can lead to considerable morbidity and mortality. As the lung is the only organ for respiration and gas exchange, the structural and functional integrity of the lung is of primary importance. Various pathological processes affect the extracellular matrix (ECM...

journal_title：Experimental lung research

authors： Chakrabarti S,Patel KD

更新日期：2005-07-01 00:00:00

abstract：:Previously, the authors have shown that tracheal occlusion (TO) partially reverses the onset of congenital diaphragmatic hernia (CDH)-induced pulmonary hypertension (PH) and abnormal pulmonary vascular development whereas release of the occlusion (TR) abolishes these clinical benefits. As a consequence of their mitoge...

journal_title：Experimental lung research

authors： Cloutier M,Seaborn T,Piedboeuf B,Bratu I,Flageole H,Laberge JM

更新日期：2005-05-01 00:00:00

abstract：:TRPV1 is a modulator of noxious stimuli known to be important in the cough reflex. We have compared the expression of TRPV1 in normal human airways and those from patients with chronic cough and found that there is up regulation in airways smooth muscle in disease. This increased expression appears to be intracellular...

journal_title：Experimental lung research

authors： Mitchell JE,Campbell AP,New NE,Sadofsky LR,Kastelik JA,Mulrennan SA,Compton SJ,Morice AH

更新日期：2005-04-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00